Go to:
Logótipo
Você está em: Start > Publications > View > The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial
Map of Premises
Principal
Publication

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

Title
The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial
Type
Article in International Scientific Journal
Year
2022
Authors
Voors, AA
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Angermann, CE
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Teerlink, JR
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Collins, SP
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Kosiborod, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Biegus, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Ferreira, JP
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Nassif, ME
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Psotka, MA
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Tromp, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Borleffs, CJW
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Ma, CS
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Comin Colet, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Fu, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Janssens, SP
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Kiss, RG
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Mentz, RJ
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Sakata, Y
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Schirmer, H
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Schou, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Schulze, PC
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Spinarova, L
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Volterrani, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Wranicz, JK
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Zeymer, U
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Zieroth, S
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Brueckmann, M
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Blatchford, JP
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Salsali, A
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Ponikowski, P
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Title: Nature MedicineImported from Authenticus Search for Journal Publications
Vol. 28
Pages: 568-574
ISSN: 1078-8956
Publisher: Springer Nature
Indexing
Other information
Authenticus ID: P-00W-88M
Resumo (PT):
Abstract (EN): The sodium-glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular death or heart failure hospitalization in patients with chronic heart failure, but whether empagliflozin also improves clinical outcomes when initiated in patients who are hospitalized for acute heart failure is unknown. In this double-blind trial (EMPULSE; NCT04157751), 530 patients with a primary diagnosis of acute de novo or decompensated chronic heart failure regardless of left ventricular ejection fraction were randomly assigned to receive empagliflozin 10 mg once daily or placebo. Patients were randomized in-hospital when clinically stable (median time from hospital admission to randomization, 3 days) and were treated for up to 90 days. The primary outcome of the trial was clinical benefit, defined as a hierarchical composite of death from any cause, number of heart failure events and time to first heart failure event, or a 5 point or greater difference in change from baseline in the Kansas City Cardiomyopathy Questionnaire Total Symptom Score at 90 days, as assessed using a win ratio. More patients treated with empagliflozin had clinical benefit compared with placebo (stratified win ratio, 1.36; 95% confidence interval, 1.09-1.68; P =0.0054), meeting the primary endpoint. Clinical benefit was observed for both acute de novo and decompensated chronic heart failure and was observed regardless of ejection fraction or the presence or absence of diabetes. Empagliflozin was well tolerated; serious adverse events were reported in 32.3% and 43.6% of the empagliflozin- and placebo-treated patients, respectively. These findings indicate that initiation of empagliflozin in patients hospitalized for acute heart failure is well tolerated and results in significant clinical benefit in the 90 days after starting treatment.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 13
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

Stress and the blood brain barrier (1997)
Another Publication in an International Scientific Journal
Azevedo, I; Sarmento A
Psychedelic treatments for mental health conditions pose challenges for informed consent (2023)
Another Publication in an International Scientific Journal
Seybert, C; Cotovio, G; Madeira, L; Ricou, Miguel; Pires, AM; Oliveira Maia, AJ
Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus (2022)
Article in International Scientific Journal
Isidro, J; Borges, V; Pinto, M; Sobral, D; Santos, JD; Nunes, A; Mixao, V; Ferreira, R; Santos, D; Duarte, S; Vieira, L; Borrego, MJ; Nuncio, S; de Carvalho, IL; Pelerito, A; Cordeiro, R; Gomes, JP
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (2020)
Article in International Scientific Journal
Kinyoki, DK; Ross, JM; Lazzar Atwood, A; Munro, SB; Schaeffer, LE; Abbasalizad Farhangi, M; Abbasi, M; Abbastabar, H; Abdelalim, A; Abdoli, A; Abdollahi, M; Abdollahpour, I; Abdulkader, RS; Abebe, ND; Abebo, TA; Abegaz, KH; Abolhassani, H; Abreu, LG; Abrigo, MRM; Abushouk, AI...(mais 908 authors)
Incident type 2 diabetes attributable to suboptimal diet in 184 countries (2023)
Article in International Scientific Journal
O¿Hearn, M; Lara Castor, L; Cudhea, F; Miller, V; Reedy, J; Shi, P; Zhang, J; Wong, JB; Economos, CD; Micha, R; Mozaffarian, D; Bas, M; Ali, JH; Abumweis, S; Krishnan, A; Misra, P; Hwalla, NC; Janakiram, C; Liputo, NI; Musaiger, A...(mais 330 authors)

See all (9)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Medicina Dentária da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-24 at 23:25:54 | Privacy Policy | Personal Data Protection Policy | Whistleblowing | Electronic Yellow Book