Photodynamic therapy and combinatory treatments for the control of biofilm-associated infections

• Type: Article in International Scientific Journal
• Date: 2022-06-10

Authors

Inês Gomes (Author) FEUP; Simões M (Author) FEUP; Ribeiro M (Author) Other; Saavedra MJ (Author) Other

Journal

Title: Letters in Applied Microbiology

Vol. 75

Pages: 548-564

ISSN: 0266-8254

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge

ISI Web of Science

Scopus

Associated Projects

ALiCE - ALiCE - Laboratório Associado em Engenharia Química

LEPABE - Financiamento Plurianual 2020-2023 da Unidade de I&D LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Biocide_for_Biofilm - Desenvolvimento de novas soluções biocidas para o controlo efetivo de biofilmes

ABFISH - Desenvolvimento de novos antibióticos para aquacultura

GermIrrad - Sistema automatizado de irradiação germicida

PRESAGE - Potencial do tratamento de águas residuais para prevenir a dispersão da resistência antimicrobiana, micropoluentes orgânicos, patogéneos e vírus

Other information

DOI: 10.1111/lam.13762

Abstract (EN): The advent of antimicrobial resistance has added considerable impact to infectious diseases both in the number of infections and healthcare costs. Furthermore, the relentless emergence of multidrug-resistant bacteria, particularly in the biofilm state, has made mandatory the discovery of new alternative antimicrobial therapies that are capable to eradicate resistant bacteria and impair the development of new forms of resistance. Amongst the therapeutic strategies for treating biofilms, antimicrobial photodynamic therapy (aPDT) has shown great potential in inactivating several clinically relevant micro-organisms, including antibiotic-resistant 'priority bacteria' declared by the WHO as critical pathogens. Its antimicrobial effect is centred on the basis that harmless low-intensity light stimulates a non-toxic dye named photosensitizer, triggering the production of reactive oxygen species upon photostimulation. In addition, combination therapies of aPDT with other antimicrobial agents (e.g. antibiotics) have also drawn considerable attention, as it is a multi-target strategy. Therefore, the present review highlights the recent advances of aPDT against biofilms, also covering progress on combination therapy.

Type (Professor's evaluation): Scientific