Regulation of neural progenitor proliferation and survival by beta 1 integrins

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Leone, DP (Author) Other; Relvas, JB (Author) Other; Campos, LS (Author) Other; Hemmi, S (Author) Other; Brakebusch, C (Author) Other; Fassler, R (Author) Other; ffrench Constant, C (Author) Other; Suter, U (Author) Other

Journal

Title: Journal of Cell Science

Vol. 118

Pages: 2589-2599

ISSN: 0021-9533

Publisher: The Company of Biologists Ltd.

Indexing

ISI Web of Knowledge - 114 Citations

Scopus - 123 Citations

Other information

Authenticus ID: P-00F-RA0

DOI: 10.1242/jcs.02396

Abstract (EN): Neural stem cells give rise to undifferentiated nestin-positive progenitors that undergo extensive cell division before differentiating into neuronal and glial cells. The precise control of this process is likely to be, at least in part, controlled by instructive cues originating from the extracellular environment. Some of these cues are interpreted by the integrin family of extracellular matrix receptors. Using neurosphere cell cultures as a model system, we show that beta 1-integrin signalling plays a crucial role in the regulation of progenitor cell proliferation, survival and migration. Following conditional genetic ablation of the beta 1-integrin allele, and consequent loss of beta 1-integrin cell surface protein, mutant nestin-positive progenitor cells proliferate less and die in higher numbers than their wild-type counterparts. Mutant progenitor cell migration on different ECM substrates is also impaired. These effects can be partially compensated by the addition of exogenous growth factors. Thus, beta 1-integrin signalling and growth factor signalling tightly interact to control the number and migratory capacity of nestin-positive progenitor cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11