TGF-beta-treated microglia induce oligodendrocyte precursor cell chemotaxis through the HGF-c-Met pathway

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Lalive, PH (Author) Other; Paglinawan, R (Author) Other; Biollaz, G (Author) Other; Kappos, EA (Author) Other; Leone, DP (Author) Other; Malipiero, U (Author) Other; Relvas, JB (Author) Other; Moransard, M (Author) Other; Suter, T (Author) Other; Fontana, A (Author) Other

Journal

Title: European Journal of Immunology

Vol. 35

Pages: 727-737

ISSN: 0014-2980

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 66 Citations

Scopus - 77 Citations

Other information

Authenticus ID: P-00F-R7B

DOI: 10.1002/eji.200425430

Abstract (EN): In acute experimental autoimmune encephalomyelitis (EAE), demyelination is induced by myelin-specific CD4(+) T lymphocytes and myelin-specific antibodies. Recovery from the disease is initiated by cytokines which suppress T cell expansion and the production of myelin-toxic molecules by macrophages. Th2/3 cell-derived signals may also be involved in central nervous system (CNS) repair. Remyelination is thought to be initiated by the recruitment and differentiation of oligodendrocyte precursor cells (OPC) in demyelinated CNS lesions. Here, we report that unlike Th1 cytokines (TNF-alpha, IFN-gamma), the Th2/3 cytokine TGF-beta induces primary microglia from C57BL/6 mice to secrete a chemotactic factor for primary OPC. We identified this factor to be the hepatocyte growth factor (HGF). Our studies show that TGF-beta-1-2-3 as well as IFN-beta induce HGF secretion by microglia and that antibodies to the HGF receptor c-Met abrogate OPC chemotaxis induced by TGF-beta 2-treated microglia. In addition we show spinal cord lesions in EAE induced in SJL/J mice to contain both OPC and HGF producing macrophages in the recovery phase, but not in the acute stage of disease. Taken these findings, TGF-beta may play a pivotal role in remyelination by inducing microglia to release HGF which is both a chemotactic and differentiation factor for OPC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11