Stage-Specific Control of Neural Crest Stem Cell Proliferation by the Small Rho GTPases Cdc42 and Rac1

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Fuchs, S (Author) Other; Herzog, D (Author) Other; Sumara, G (Author) Other; Buechmann Moller, S (Author) Other; Civenni, G (Author) Other; Wu, XW (Author) Other; Chrostek Grashoff, A (Author) Other; Suter, U (Author) Other; Ricci, R (Author) Other; Relvas, JB (Author) Other; Brakebusch, C (Author) Other; Sommer, L (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: CELL STEM CELL

Vol. 4

Pages: 236-247

ISSN: 1934-5909

Indexing

ISI Web of Knowledge - 62 Citations

Scopus - 78 Citations

Other information

Authenticus ID: P-009-EJG

DOI: 10.1016/j.stem.2009.01.017

Abstract (EN): The neural crest (NC) generates a variety of neural and non-neural tissues during vertebrate development. Both migratory NC cells and their target structures contain cells with stem cell features. Here we show that these populations of neural crest-derived stem cells (NCSCs) are differentially regulated by small Rho GTPases. Deletion of either Cdc42 or Rac1 in the NC results in size reduction of multiple NC target structures because of increased cell-cycle exit, while NC cells emigrating from the neural tube are not affected. Consistently, Cdc42 or Rac1 inactivation reduces self-renewal and proliferation of later stage, but not early migratory NCSCs. This stage-specific requirement for small Rho GTPases is due to changes in NCSCs that, during development, acquire responsiveness to mitogenic EGF acting upstream of both Cdc42 and Rac1. Thus, our data reveal distinct mechanisms for growth control of NCSCs from different developmental stages.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12