Go to:
Logótipo
Você está em: Start > Publications > View > Morphofunctional programming of microglia requires distinct roles of type II myosins
Map of Premises
Principal
Publication

Morphofunctional programming of microglia requires distinct roles of type II myosins

Title
Morphofunctional programming of microglia requires distinct roles of type II myosins
Type
Article in International Scientific Journal
Year
2021
Authors
Melo, PN
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
da Silveira, MS
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Pinto, IM
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Relvas, JB
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Journal
Title: GLIAImported from Authenticus Search for Journal Publications
ISSN: 0894-1491
Publisher: Wiley-Blackwell
Indexing
Publicação em ISI Web of Knowledge ISI Web of Knowledge - 0 Citations
Other information
Authenticus ID: P-00V-8B2
Abstract (EN): The ramified morphology of microglia and the dynamics of their membrane protrusions are essential for their functions in central nervous system development, homeostasis, and disease. Although their ability to change and control shape critically depends on the actin and actomyosin cytoskeleton, the underlying regulatory mechanisms remain largely unknown. In this study, we systematically analyzed the actomyosin cytoskeleton and regulators downstream of the small GTPase RhoA in the control of microglia shape and function. Our results reveal that (i) Myh9 controls cortical tension levels and affects microglia protrusion formation, (ii) cofilin-mediated maintenance of actin turnover regulates microglia protrusion extension, and (iii) Myh10 influences microglia inflammatory activation. Overall we uncover molecular pathways that regulate microglia morphology and identify type-II myosins as important regulators of microglia biology with differential roles in the control of cell shape (Myh9) and functions (Myh10).
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 22
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

The Function of RhoGTPases in Axon Ensheathment and Myelination (2008)
Another Publication in an International Scientific Journal
Feltri, ML; Suter, U; Relvas, JB
Mechanical plasticity during oligodendrocyte differentiation and myelination (2018)
Another Publication in an International Scientific Journal
Domingues, HS; Cruz, A; Chan, JR; Relvas, JB; Rubinstein, B; Pinto, IM
Jmy regulates oligodendrocyte differentiation via modulation of actin cytoskeleton dynamics (2018)
Article in International Scientific Journal
Azevedo, MM; Domingues, HS; Cordelieres, FP; Sampaio, P; Seixas, AI; Relvas, JB
Gelsolin Is Required for Macrophage Recruitment During Remyelination of the Peripheral Nervous System (2010)
Article in International Scientific Journal
Goncalves, AF; Dias, NG; Moransard, M; Correia, R; Pereira, JA; Witke, W; Suter, U; Relvas, JB
Drosophila PS2 and PS3 Integrins Play Distinct Roles in Retinal Photoreceptors-Glia Interactions (2015)
Article in International Scientific Journal
Tavares, L; Pereira, E; Correia, A; Santos, MA; Amaral, N; Martins, T; Relvas, JB; Pereira, PS

See all (6)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Medicina Dentária da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-08-08 at 21:55:12 | Privacy Policy | Personal Data Protection Policy | Whistleblowing | Electronic Yellow Book