High levels of immunoglobulin A anti-tissue transglutaminase antibodies at diagnosis are a predictive factor for celiac hepatitis

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Albuquerque, A (Author) Other; Rodrigues, S (Author) Other; Macedo G (Author) FMUP

Journal

Title: Scandinavian Journal of Gastroenterology

Vol. 51

Pages: 1316-1320

ISSN: 0036-5521

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 3 Citations

Other information

Authenticus ID: P-00M-5GQ

DOI: 10.1080/00365521.2016.1203017

Abstract (EN): Introduction: Celiac hepatitis is characterized by the presence of liver injury in patients with celiac disease that resolves after gluten-free diet.Aim: To evaluate predictive factors of celiac hepatitis at celiac disease diagnosis.Methods: Retrospective study including 46 adult patients with the diagnosis of celiac disease.Results: Eighty-seven percent were women, with a mean age of 3311 years, 87% had a Marsh 3 and 46% (n=21) had celiac hepatitis. These patients had a median Immunoglobulin A anti-tissue transglutaminase antibody (TTG-IgA) level of 208.0U/ml (p25-p75: 89-1316U/ml), a mean aspartate aminotransferase of 42 +/- 24U/L, alanine aminotransferase 50 +/- 28U/L, alkaline phosphatase 111 +/- 64U/L, at the time of diagnosis. Median TTG-IgA one year after diagnosis was 9U/ml (p25-p75: 4.5-30.5U/ml) and 33% of the patients had normal values. At diagnosis, patients without celiac hepatitis had a median TTG-IgA of 77U/ml (p25-p75: 24-288U/ml), mean aspartate aminotransferase of 23 +/- 4U/L, alanine aminotransferase 20 +/- 6U/L, alkaline phosphatase 69 +/- 17U/L. Median of TTG-IgA one year after diagnosis was 6U/ml (p25-p75: 3-19U/ml) and 48% had normal values. The celiac hepatitis group patients had higher values of TTG-IgA (p=0.007) at diagnosis. There was a statistically significant positive correlation between TTG-IgA and alanine aminotransferase (r=0.324, p=0.028) at diagnosis. The odds of having celiac hepatitis was almost 5-fold higher in patients with a TTG-IgA level higher than 310U/ml (OR=4.8, 95%CI=1.213-18.781, p=0.025).Conclusions: Higher TTG-IgA levels are a predictive factor for celiac hepatitis in adult patients with celiac disease at diagnosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5