Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Magalhaes, JD (Author) Other; Fao, L (Author) Other; Vilaca, R (Author) Other; Cardoso, SM (Author) Other; Rego, AC (Author) Other

Journal

Title: Biomedicines

Vol. 9

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-TN3

DOI: 10.3390/biomedicines9111625

Abstract (EN): Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer's, Parkinson's, and Huntington's diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as A beta, tau, alpha-synuclein (alpha-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 46