An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Li Bassi, G (Author) Other; Suen, JY (Author) Other; Dalton, HJ (Author) Other; White, N (Author) Other; Shrapnel, S (Author) Other; Fanning, JP (Author) Other; Liquet, B (Author) Other; Hinton, S (Author) Other; Vuorinen, A (Author) Other; Booth, G (Author) Other; Millar, JE (Author) Other; Forsyth, S (Author) Other; Panigada, M (Author) Other; Laffey, J (Author) Other; Brodie, D (Author) Other; Fan, E (Author) Other; Torres, A (Author) Other; Chiumello, D (Author) Other; Corley, A (Author) Other; Elhazmi, A (Author) Other; Hodgson, C (Author) Other; Ichiba, S (Author) Other; Luna, C (Author) Other; Murthy, S (Author) Other; Nichol, A (Author) Other; Ng, PY (Author) Other; Ogino, M (Author) Other; Pesenti, A (Author) Other; Trieu, HT (Author) Other; Fraser, JF (Author) Other; Al-Dabbous, T (Author) Other; Alfoudri, H (Author) Other; Shamsah, M (Author) Other; Elapavaluru, S (Author) Other; Berg, A (Author) Other; Horn, C (Author) Other; Schroll, S (Author) Other; Velazco, J (Author) Other; Fikes, W (Author) Other; Ploskanych, L (Author) Other; Meyer, D (Author) Other; Shalabi-McGuire, M (Author) Other; Witt, T (Author) Other; Ehlers, A (Author) Other; Grazioli, L (Author) Other; Grandin, EW (Author) Other; Nunez, J (Author) Other; Reyes, T (Author) Other; Joseph, M (Author) Other; Mitchell, B (Author) Other; Tenzer, M (Author) Other; Abe, R (Author) Other; Hayashi, Y (Author) Other; Cho, HJ (Author) Other; Jeong, IS (Author) Other; Brozzi, N (Author) Other; Hernandez-Montfort, J (Author) Other; Mehkri, O (Author) Other; Houltham, S (Author) Other; Graf, J (Author) Other; Perez, R (Author) Other; Diaz, R (Author) Other; Delgado, C (Author) Other; González, J (Author) Other; Sanchez, MS (Author) Other; Rincón, DFB (Author) Other; Duque, MB (Author) Other; Yanten, AMM (Author) Other; Brodie, D (Author) Other; Rusmawatiningtyas, D (Author) Other; Ragazzo, G (Author) Other; Taufik, A (Author) Other; Gunawan, M (Author) Other; Irawany, V (Author) Other; Rayhan, M (Author) Other; Wardoyo, EY (Author) Other; Panigada, M (Author) Other; Coppola, S (Author) Other; Colombo, S (Author) Other; Grasselli, G (Author) Other; Leone, M (Author) Other; Zanella, A (Author) Other; Antonelli, M (Author) Other; Carelli, S (Author) Other; Grieco, DL (Author) Other; Asaki, M (Author) Other; Hoshino, K (Author) Other; Salazar, L (Author) Other; Duarte, L (Author) Other; McCaffrey, J (Author) Other; Bone, A (Author) Other; Thomson, D (Author) Other; Arnold-Day, C (Author) Other; Cupido, J (Author) Other; Fanie, Z (Author) Other; Miller, M (Author) Other; Seymore, L (Author) Other; van Straaten, D (Author) Other; Hassan, I (Author) Other; Hssain, AA (Author) Other; Aliudin, J (Author) Other; Alqahtani, A (Author) Other; Mohamed, K (Author) Other; Mohamed, A (Author) Other; Tan, D (Author) Other; Villanueva, J (Author) Other; Zaqout, A (Author) Other; Kurtzman, E (Author) Other; Ademi, A (Author) Other; Dobrita, A (Author) Other; Aoudi, KE (Author) Other; Segura, J (Author) Other; Giwangkancana, G (Author) Other; Ohshimo, S (Author) Other; Hoshino, K (Author) Other; Hitoshi, S (Author) Other; Uchinami, Y (Author) Other; Osatnik, J (Author) Other; Joosten, A (Author) Other; Torres, A (Author) Other; Motos, A (Author) Other; Yang, M (Author) Other; Luna, C (Author) Other; Arancibia, F (Author) Other; Williams, V (Author) Other; Noel, A (Author) Other; Luque, N (Author) Other; Trung, TH (Author) Other; Yacoub, S (Author) Other; Fantini, M (Author) Other; García, RNJ (Author) Other; Alvarez, EC (Author) Other; Greti, A (Author) Other; Lomeli, O (Author) Other; Ceccato, A (Author) Other; Sanchez, A (Author) Other; Vazquez, AL (Author) Other; Roche-Campo, F (Author) Other; Tuazon, D (Author) Other; Duculan, T (Author) Other; Shimizu, H (Author) Other; Amato, M (Author) Other; Cassimiro, L (Author) Other; Pola, F (Author) Other; Ribeiro, F (Author) Other; Fonseca, G (Author) Other; Dalton, H (Author) Other; Desai, M (Author) Other; Osborn, E (Author) Other; Deeb, H (Author) Other; Arcadipane, A (Author) Other; Bianco, C (Author) Other; Cuffaro, R (Author) Other; Martucci, G (Author) Other; Occhipinti, G (Author) Other; Rossetti, M (Author) Other; Vitiello, C (Author) Other; Cho, S (Author) Other; Calligy, K (Author) Other; Whitman, G (Author) Other; Shimizu, H (Author) Other; Moriyama, N (Author) Other; Kim, J (Author) Other; Kitamura, N (Author) Other; Shimazui, T (Author) Other; Al-Hudaib, A (Author) Other; Elhazmi, A (Author) Other; Gebauer, J (Author) Other; Yokoyama, T (Author) Other; Al-Fares, A (Author) Other; Alamad, E (Author) Other; Alawadhi, F (Author) Other; Alawadi, K (Author) Other; Buabbas, S (Author) Other; Tanaka, H (Author) Other; Hashimoto, S (Author) Other; Yamazaki, M (Author) Other; Oh, T (Author) Other; Epler, M (Author) Other; Forney, C (Author) Other; Feister, J (Author) Other; Grobengieser, K (Author) Other; Kruse, L (Author) Other; Williamson, J (Author) Other; Gnall, E (Author) Other; Caroline, M (Author) Other; Golden, S (Author) Other; Karaj, C (Author) Other; McDermott, S (Author) Other; Sher, L (Author) Other; Shapiro, T (Author) Other; Thome, L (Author) Other; Vanderland, M (Author) Other; Welch, M (Author) Other; Brazzi, L (Author) Other; Ogston, T (Author) Other; Nagpal, D (Author) Other; Fischer, K (Author) Other; Lorusso, R (Author) Other; de Piero, M (Author) Other; Esperatti, M (Author) Other; O¿Briain, D (Author) Other; Carton, EG (Author) Other; Sen, A (Author) Other; Palacios, A (Author) Other; Rainey, D (Author) Other; Seefeldt, C (Author) Other; Durham, L (Author) Other; Falcucci, O (Author) Other; Emmrich, A (Author) Other; Guy, J (Author) Other; Johns, C (Author) Other; Neumann, E (Author) Other; Buchtele, N (Author) Other; Schwameis, M (Author) Other; Stecher, S (Author) Other; Singh, D (Author) Other; Barnikel, M (Author) Other; Arenz, L (Author) Other; Zaaqoq, A (Author) Other; Galloway, LA (Author) Other; Merley, C (Author) Other; Csete, M (Author) Other; Quesada, L (Author) Other; Saba, I (Author) Other; Kasugai, D (Author) Other; Hiraiwa, H (Author) Other; Tanaka, T (Author) Other; Marwali, E (Author) Other; Purnama, Y (Author) Other; Dewayanti, SR (Author) Other; Ardiyan (Author) Other; Siagian, D (Author) Other; Chen, Y (Author) Other; Laffey, J (Author) Other; McNicholas, B (Author) Other; Cosgrave, D (Author) Other; VanDyk, M (Author) Other; MacDonald, S (Author) Other; Seppelt, I (Author) Other; Ratsep, I (Author) Other; Enneveer, L (Author) Other; Erikson, K (Author) Other; Oigus, G (Author) Other; Post, A (Author) Other; Sillaots, P (Author) Other; Manetta, F (Author) Other; Komats, M (Author) Other; Satyapriya, SV (Author) Other; Bhatt, A (Author) Other; Echeverria, M (Author) Other; Fiorda, J (Author) Other; Gonzalez, A (Author) Other; Mokadam, NA (Author) Other; McKeown, J (Author) Other; Pasek, J (Author) Other; Shi, H (Author) Other; Uribe, A (Author) Other; Moreno, R (Author) Other; Zakhary, B (Author) Other; Johnson, H (Author) Other; Pow, N (Author) Other; Cavana, M (Author) Other; Cucino, A (Author) Other; Foti, G (Author) Other; Giani, M (Author) Other; Russotto, V (Author) Other; Chiumello, D (Author) Other; Castagna, V (Author) Other; Dell¿Amore, A (Author) Other; Shum, H (Author) Other; Vuysteke, A (Author) Other; Usman, A (Author) Other; Acker, A (Author) Other; Mergler, B (Author) Other; Rizer, N (Author) Other; Sertic, F (Author) Other; Smood, B (Author) Other; Sperry, A (Author) Other; Subramanian, M (Author) Other; Lolong, N (Author) Other; Akmal, E (Author) Other; Burhan, E (Author) Other; Rasmin, M (Author) Other; Naivedh, B (Author) Other; Sitompu, F (Author) Other; Barrett, P (Author) Other; Daugherty, J (Author) Other; Dean, D (Author) Other; Loforte, A (Author) Other; Khan, I (Author) Other; DeSantis, O (Author) Other; Quraishi, MA (Author) Other; Salt, G (Author) Other; So, D (Author) Other; Kandamby, D (Author) Other; Mandei, JM (Author) Other; Natanael, H (Author) Other; YudhaLantang, E (Author) Other; Lantang, A (Author) Other; Jung, A (Author) Other; Hammond, T (Author) Other; Ng, G (Author) Other; Ng, WY (Author) Other; Yeung, P (Author) Other; Adachi, S (Author) Other; Blanco, P (Author) Other; Prieto, A (Author) Other; Sánchez, J (Author) Other; Nicholson, M (Author) Other; Farquharson, M (Author) Other; Butt, W (Author) Other; Serratore, A (Author) Other; Delzoppo, C (Author) Other; Janin, P (Author) Other; Yarad, E (Author) Other; Totaro, R (Author) Other; Coles, J (Author) Other; Balk, R (Author) Other; Fox, S (Author) Other; Hays, J (Author) Other; Kapania, E (Author) Other; Mishin, P (Author) Other; Vissing, A (Author) Other; Yantosh, G (Author) Other; Yuliarto, S (Author) Other; Santoso, KH (Author) Other; Djajalaksana, S (Author) Other; Fatoni, AZ (Author) Other; Fukuda, M (Author) Other; Liu, K (Author) Other; Pelosi, P (Author) Other; Battaglini, D (Author) Other; Jiménez, JFM (Author) Other; Gaião, S (Author) Other; Roncon-Albuquerque R Jr (Author) FMUP; Buchner, J (Author) Other; Cho, Y (Author) Other; Lee, SM (Author) Other; Lee, SH (Author) Other; Kawasaki, T (Author) Other; Sakiyalak, P (Author) Other; Nitayavardhana, P (Author) Other; Seitz, T (Author) Other; Arora, R (Author) Other; Kent, D (Author) Other; Parwar, S (Author) Other; Cheng, A (Author) Other; Miller, J (Author) Other; Marino, D (Author) Other; Deacon, JE (Author) Other; Fujitani, S (Author) Other; Shimizu, N (Author) Other; Madhok, J (Author) Other; Owyang, C (Author) Other; Buscher, H (Author) Other; Reynolds, C (Author) Other; Maasikas, O (Author) Other; Beljantsev, A (Author) Other; Mihnovits, V (Author) Other; Akimoto, T (Author) Other; Aizawa, M (Author) Other; Horibe, K (Author) Other; Onodera, R (Author) Other; Hodgson, C (Author) Other; Young, M (Author) Other; Smith, T (Author) Other; Bartone, C (Author) Other; George, T (Author) Other; Shekar, K (Author) Other; McGuinness, N (Author) Other; Irvine, L (Author) Other; Flynn, B (Author) Other; Houchin, A (Author) Other; Shimizu, K (Author) Other; Hamaguchi, J (Author) Other; Lussier, L (Author) Other; Kersker, G (Author) Other; Reich, JA (Author) Other; Lotz, G (Author) Other; Malfertheiner, M (Author) Other; Dreier, E (Author) Other; Maier, L (Author) Other; Kusumastuti, NP (Author) Other; McCloskey, C (Author) Other; Dabaliz, A (Author) Other; Elshazly, TB (Author) Other; Smith, J (Author) Other; Szuldrzynski, KS (Author) Other; Biela¿ski, P (Author) Other; Hakeem, Y (Author) Other; Wille, K (Author) Other; Holt, R (Author) Other; Parhar, KKS (Author) Other; Fiest, KM (Author) Other; Codan, C (Author) Other; Shahid, A (Author) Other; Fayed, M (Author) Other; Evans, T (Author) Other; Garcia, R (Author) Other; Gutierrez, A (Author) Other; Shimizu, H (Author) Other; Song, T (Author) Other; Rose, R (Author) Other; Bennett, S (Author) Other; Richardson, D (Author) Other; Peek, G (Author) Other; Lopez-Colon, D (Author) Other; Arora, L (Author) Other; Rappapport, K (Author) Other; Rudolph, K (Author) Other; Sibenaller, Z (Author) Other; Stout, L (Author) Other; Walter, A (Author) Other; Herr, D (Author) Other; Vedadi, N (Author) Other; Sindt, L (Author) Other; Ewald, C (Author) Other; Hoffman, J (Author) Other; Rajnic, S (Author) Other; Thompson, S (Author) Other; Kennedy, R (Author) Other; Griffee, M (Author) Other; Ciullo, A (Author) Other; Kida, Y (Author) Other; Roca, RF (Author) Other; Alegre, C (Author) Other; Contreras, S (Author) Other; Riera, J (Author) Other; Kay, C (Author) Other; Fischer, I (Author) Other; Renner, E (Author) Other; Taniguci, H (Author) Other; Abbate, G (Author) Other; Hassan, H (Author) Other; Heinsar, S (Author) Other; Karnik, VA (Author) Other; Ki, K (Author) Other; O¿Neill, HF (Author) Other; Obonyo, N (Author) Other; Pimenta, LP (Author) Other; Reid, JD (Author) Other; Sato, K (Author) Other; Shekar, K (Author) Other; Vuorinen, A (Author) Other; Wildi, KS (Author) Other; Wood, ES (Author) Other; Yerkovich, S (Author) Other

Journal

Title: Critical Care

Vol. 21

ISSN: 1364-8535

Publisher: Springer Nature

Other information

Authenticus ID: P-00W-BXP

DOI: 10.1186/s13054-021-03518-4

Abstract (EN): <jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Heterogeneous respiratory system static compliance (<jats:italic>C</jats:italic><jats:sub>RS</jats:sub>) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe <jats:italic>C</jats:italic><jats:sub>RS</jats:sub>¿calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)]¿and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> within the first seven days of MV. Median (IQR) age was 62 (52¿71), patients were predominantly males (68%) and from Europe/North and South America (88%). <jats:italic>C</jats:italic><jats:sub>RS</jats:sub>, within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (<jats:italic>p</jats:italic>¿=¿0.417) nor with PaO<jats:sub>2</jats:sub>/FiO<jats:sub>2</jats:sub> (<jats:italic>p</jats:italic>¿=¿0.100). Females presented lower <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> than males (95% CI of <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> difference between females-males: ¿¿11.8 to ¿¿7.4 mL/cmH<jats:sub>2</jats:sub>O <jats:italic>p</jats:italic>¿<¿0.001), and although females presented higher body mass index (BMI), association of BMI with <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> was marginal (<jats:italic>p</jats:italic>¿=¿0.139). Ventilatory management varied across <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> range, resulting in a significant association between <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> and driving pressure (estimated decrease ¿¿0.31 cmH<jats:sub>2</jats:sub>O/L per mL/cmH<jats:sub>2</jats:sub>0 of <jats:italic>C</jats:italic><jats:sub>RS</jats:sub>, 95% CI ¿¿0.48 to ¿¿0.14, <jats:italic>p</jats:italic>¿<¿0.001). Overall, 28-day ICU mortality, accounting for the competing risk of being discharged within the period, was 35.6% (SE 1.7). Cox proportional hazard analysis demonstrated that <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> (+¿10 mL/cm H<jats:sub>2</jats:sub>O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02¿1.28, <jats:italic>p</jats:italic>¿=¿0.018).</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>This multicentre report provides a comprehensive account of <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> in COVID-19 patients on MV. <jats:italic>C</jats:italic><jats:sub>RS</jats:sub> measured within 48 h from commencement of MV has marginal predictive value for 28-day mortality, but was associated with being d

Language: English

Type (Professor's evaluation): Dissemination