The Mitotic Spindle

• Type: Chapter or Part of a Book
• Date: 2015

Authors

Barisic, M (Author) Other; Helder Maiato (Author) FMUP

Book

Title: Encyclopedia of Cell Biology

Pages: 637-648

ISBN: 9780123944474; 9780123947963

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00N-QP7

DOI: 10.1016/b978-0-12-394447-4.20062-x

Abstract (EN): The mitotic spindle is a microtubule-made machine required for chromosome segregation during mitosis. Several pathways and molecules contribute to the assembly of this structure, which shows intrinsic dynamic properties. The dynamic nature of spindle microtubules plays a key role in error correction, as well as in the generation of force necessary to move chromosomes. Additionally, several molecular motors use spindle microtubules as tracks and, together with microtubule stabilizing as well as destabilizing proteins, they participate in proper spindle assembly and function. Here we summarize the essential concepts and principles behind the formation of this robust chromosome segregation machine.

Language: English

Type (Professor's evaluation): Scientific