Increase in renal production of dopamine after the administration of radiographic contrast agents [Aumento na producao renal de dopamina apos a administracao de agentes de contraste radiografico]

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Santos, J (Author) Other; Araujo, V (Author) Other; Moura, L (Author) Other; Maria Paula Serrão (Author) REIT; Guerra, L (Author) Other; Maciel, J (Author) Other; Pestana M (Author) FMUP

Journal

Title: Revista Portuguesa de Cardiologia

Vol. 17 No. 5

Pages: 1007-1011

ISSN: 0870-2551

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-007-85J

Abstract (EN): Renal vascoconstriction and anti-natriuresis conditioned by radiographic contrast agents (CA) may be antagonised by the administration of exogenous dopamine. However, the influence of CA on the activity of renal synthesis of dopamine has not been studied. This study assessed the daily urinary excretion of dopamine, its precursor. L-3, 4 - dihydroxyphenylaline (L- DOPA), and its metabolites (acid 3, 4-dihydroxyphenylacetic, DOPAC; homovanillic acid, HVA) 24 hours before and 48 hours following administration of a non ionic and hyposmolar (Iopromide) CA in patients (n = 10; average age 61.3 ± 4.3 years) submitted to coronary angiography. Urinary excretion of noradrenalin, a marker of sympathetic activity, was also assessed during the same period. The deputation of creatinine (Ccr) and the urinary excretion of sodium (UNa+) lowered after the administration of the CA (Ccr, 79.2 ± 10.2 vs 72.2 ± 9.6 ml/min/1.73 m2, p < 0.05; UNa+, 112.8 ± 9.6 vs 61.7 ± 25.1 mmol/24 h, p < 0.05). On the contrary, the urinary excretion of potassium increased in the period of 24 h following the administration of the AC (31.7 ± 5.2 vs 103.8 ± 10.8 mmol/24 h, p < 0.05). There was an increase in the urinary excretion of dopamine as well as noradrelalin during the 24 hour period following the administration of the CA (dopamine, 1260.2 ± 196.8 vs 1571.5 ± 170.2 mmol/24 h p < 0.5; noradrenalin, 186 ± 36.6 mmol/24 h, p < 0.05). On the contrary, the urinary excretion of L-DOPA lowered after the administration of the CA (115.4 ± 25.5 vs 80.5 ± 13.2 mmol/24 h, p < 0.05). These results conditioned an increase in the dopamine/L-DOPA ratio in the urine, after the administration of the CA (12.2 ± 1.5 vs 22.2 ± 4.5 mmol/24 h, p < 0.05). In conclusion, the administration of CA is accompanied by an increase in the renal production of dopamine which, in these conditions, may act as a compensatory natriuretic hormone.

Language: Portuguese

Type (Professor's evaluation): Scientific