SGLT-2 Inhibitors in Heart Failure and Type-2 Diabetes: Hitting Two Birds with One Stone?

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Santos Ferreira, D (Author) FMUP; Goncalves Teixeira, P (Author) Other; Fontes-Carvalho R (Author) FMUP

Journal

Title: Cardiology

Vol. 145

Pages: 311-320

ISSN: 0008-6312

Publisher: Karger

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-00R-K5C

DOI: 10.1159/000504694

Abstract (EN): Type 2 diabetes mellitus (T2DM) and heart failure (HF) have a tremendous impact worldwide, markedly reducing life-expectancy and quality of life. It is now known that each disease represents a risk factor for the other. Moreover, when they are combined, the prognosis is significantly worse. Until recently, these pathologies have been managed independently. However, their treatment paradigm is rapidly changing, with recent cardiovascular outcome trials showing that sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are effective in the management of both diseases. This article explores the interactions between T2DM and HF and the concept of diabetic cardiomyopathy and summarizes recent data regarding the effects of SGLT-2i on HF hospitalization and the proposed pathophysiological mechanisms involved.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10