Cytokine gene polymorphisms in pigeon breeder's disease expression

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Freitas, C (Author) Other; Lima, B (Author) Other; Martins, N (Author) Other; Melo, N (Author) Other; Mota, P (Author) Other; Novais Bastos, H (Author) Other; Alves, H (Author) Other; Sokhatska, O (Author) FMUP; Delgado, L (Author) FMUP; Morais, A (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Sarcoidosis Vasculitis and Diffuse Lung Diseases

Vol. 37

ISSN: 1124-0490

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 2 Citations

Other information

Authenticus ID: P-00T-N9A

DOI: 10.36141/svdld.v37i3.9342

Abstract (EN): Background: Exaggerated immunological response to repeated inhalation of organic or chemical dusts may lead to Hypersensitivity Pneumonitis among sensitized individuals. Only a few exposed individuals became ill and disease expression pattern is highly variable which suggest that genetic factors may play a role. Aim: To investigate interferon (IFN)-¿, tumour necrosis factor (TNF)-¿, interleukin (IL)-6, transforming growth factor (TGF)-ß, and IL-10 gene polymorphisms in a cohort of pigeon breeder's disease (PBD) patients in comparison with exposed but healthy controls and the association with different patterns of disease. Methods: We evaluated 40 PBD patients and 70 exposed controls. IFN-¿, TNF-¿, IL-6, TGF-ß, and IL-10 polymorphisms were determined by polymerase chain reaction-sequence specific primer amplification. Results: Polymorphism analysis of IFN-¿, TNF-¿, IL-6, TGF-ß, and IL-10 genotypes and allele frequencies showed no differences between patients and controls. IFN-¿ T/T genotype frequency was increased among patients with chronic presentation (RR=2.33, p=0.047) compared with those with acute/subacute presentation. Also, chronic presenting patients had an increased frequency of IFN-¿ T allele (50% vs 22.5%, RR=1.76, p=0.011). No differences were found in TNF-¿, IL-6, TGF-ß, and IL-10 genotypes neither allelic frequencies between both groups of patients. IL-6 C/C genotype was more frequent in patients who showed chronic evolution (RR=2.54, p=0.017), when comparing with patients with disease resolution. Conclusion: IFN-¿ T/T and the IL-6 C/C genotypes seem to play a role in HP expression due to avian exposure, as their frequencies are increased in chronic presentations or in those with chronic evolution one year after the initial diagnosis, respectively. © Mattioli 1885.

Language: English

Type (Professor's evaluation): Scientific