Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Ciccarelli, M (Author) Other; Dawson, D (Author) Other; Falcao Pires, I (Author) FMUP; Giacca, M (Author) Other; Hamdani, N (Author) Other; Heymans, S (Author) Other; Hooghiemstra, A (Author) Other; Leeuwis, A (Author) Other; Hermkens, D (Author) Other; Tocchetti, CG (Author) Other; van der Velden, J (Author) Other; Zacchigna, S (Author) Other; Thum, T (Author) Other

Journal

Title: Cardiovascular Research

Vol. 117

Pages: 2416-2433

ISSN: 0008-6363

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 20 Citations

Other information

Authenticus ID: P-00T-EQ3

DOI: 10.1093/cvr/cvab009

Abstract (EN): Heart failure-either with reduced or preserved ejection fraction (HFrEF/HFpEF)-is a clinical syndrome of multi-factorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body's needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numerous cancer types. In this position paper, we provide an overview regarding interactions between the heart and other organ systems, the clinical evidence, underlying mechanisms, potential available or yet-to-establish animal models to study such interactions and finally discuss potential new drug interventions to be developed in the future. Our working group suggests that more experimental research is required to understand the individual molecular mechanisms underlying heart failure and reinforces the urgency for tailored therapeutic interventions that target not only the heart but also other related affected organ systems to effectively treat heart failure as a clinical syndrome that affects and involves multiple organs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18