Worse cardiac remodeling in response to pressure overload in type 2 diabetes mellitus

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Goncalves, N (Author) FMUP; Gomes Ferreira, C (Author) Other; Moura, C (Author) Other; Roncon-Albuquerque R Jr (Author) FMUP; Leite-Moreira AF (Author) FMUP; Falcao Pires, I (Author) FMUP

Journal

Title: International Journal of Cardiology

Vol. 217

Pages: 195-204

ISSN: 0167-5273

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00K-K1Z

DOI: 10.1016/j.ijcard.2016.04.178

Abstract (EN): Background: Diabetic cardiomyopathy is characterized by cardiac structural and functional abnormalities. Additionally, chronic pressure overload conditions are highly prevalent amongst diabetic population and this association leads to a more severe myocardial impairment. The differences in myocardial pathophysiology between type 1 and type 2 diabetes mellitus (DM) still remain to be clarified. Thus, we aimed to investigate biventricular structural and functional changes promoted by the two types of DM and the impact of concomitant chronic pressure overload. Methods: Wistar rats were injected with streptozotocin (Type 1 DM, T1DM) or fed with a hypercaloric diet (Type 2 DM, T2DM). Pressure overload was imposed in DM animals by aortic constriction and after 5 weeks of DM the cardiac function and structure were evaluated. Results: Both types of DM promoted hypertrophy, increased fibrosis and advanced glycation end-products deposition, in the two ventricles. Interestingly, the induced myocardial alterations were distinct. While T1DM stimulated a pronounced hypertrophy and extracellular matrix remodeling, T2DM induced functional impairment. The negative impact of the association of DM with aortic constriction was more pronounced in T2DM, promoting impaired function and increased stiffness, particularly in the right ventricle. Conclusions: Our study demonstrated that the two types of diabetes induce distinct cardiac alterations per se or when combined with chronic pressure overload. T1DM promoted a more extensive remodeling in cardiac structure while T2DM significantly impaired ventricular function. The impact of pressure overload was more notorious in T2DM as observed by worse myocardial remodeling, suggesting a higher susceptibility to the deleterious effects of chronic pressure overload, namely hypertension, among this diabetic population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10