Pathophysiologic aspects of myocardial relaxation and end-diastolic stiffness of cardiac ventricles

• Type: Chapter or Part of a Book
• Date: 2008

Authors

Gillebert, TC (Author) Other; Leite-Moreira AF (Author) FMUP

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-008-Z3P

DOI: 10.1007/978-1-84628-891-3_2

Abstract (EN): Cardiovascular congestion with preserved ejection fraction is not necessarily diastolic heart failure. Diastolic left ventricular dysfunction may be induced by overload, is present in systolic heart failure, and is the hallmark of diastolic heart failure. Distensibility, compliance, and left ventricular size are the main determinants of the diastolic pressure-volume relation. Myocardial relaxation may importantly affect end-diastolic left ventricular properties. Knowledge of intracellular calcium fluxes is essential to understand myocardial relaxation. Myocardial stiffness is regulated by extracellular matrix, by the cytoskeleton, and by myofilament interaction. Myocardial tone is regulated by phosphorylation of myofilaments, load, endothelin-1, ß-adrenergic receptor stimulation, and angiotensin II. Diastolic heart failure is a combined disorder due to increased stiffness of heart and vessels. © 2008 Springer-Verlag London Limited.

Language: English

Type (Professor's evaluation): Scientific