Apelin: A novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target [Apelina: Um novo modulador neuro-humoral do aparelho cardiovascular]

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

Falcao Pires, I (Author) Other; Leite-Moreira AF (Author) FMUP

Journal

Title: Revista Portuguesa de Cardiologia

Vol. 24 No. 11

Pages: 1263-1276

ISSN: 0870-2551

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

Scopus - 48 Citations

Other information

Authenticus ID: P-007-EFS

Abstract (EN): Apelin is a recently discovered vasoactive peptide that has been demonstrated to be the endogenous ligand of the APJ receptor. It was named 'apelin' after APJ endogenous ligand. This G protein-coupled receptor (GPCR), originally identified by O'Dowd et al. in 1993, has a close identity with the angiotensin II type 1 (AT1) receptor, bot does not bind angiotensin-II. Although apelin and APJ have been found to be ubiquitously expressed in peripheral tissues, particularly the heart and lungs, as well as various regions of the central nervous system, the physiologic actions of apelin remain largely unknown. Nevertheless, some cardiovascular functions of the apelin/APJ system have been described, such as endothelium-dependent vasodilatation, vasoconstriction by direct action on the smooth muscle and positive inotropism. Other reported physiologic actions of apelin include: 1) its role as endocrine adipokine; 2) contribution to fluid homeostasis and thirst regulation; 3) participation as coreceptor in the process of human immunodeficiency virus type 1 infection; and 4) regulation of immune response. The involvement of apelin/APJ in the pathophysiology of heart failure (HF) and its potential as a therapeutic target in this syndrome have also been proposed. In the course of HF progression, plasma levels of apelin are significantly increased in the early stages, decreasing progressively towards normal in the advanced stages of the disease. Given the increasing number of studies focusing on the apelin/APJ system, the goal of this paper was to make an up-to-date review of existing information on apelin and APJ, with particular focus on their cardiovascular actions and potential use as a therapeutic target in HF.

Language: English

Type (Professor's evaluation): Scientific