Beyond gut microbiota: understanding obesity and type 2 diabetes

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Lau, E (Author) FMUP; Carvalho, Davide (Author) FMUP; pina-vaz, c (Author) FMUP; José Barbosa (Author) FMUP; Freitas, P (Author) FMUP

Journal

Title: HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM

Vol. 14

Pages: 358-369

ISSN: 1109-3099

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 41 Citations

Other information

Authenticus ID: P-00G-MV9

DOI: 10.14310/horm.2002.1571

Abstract (EN): Obesity and type 2 diabetes are metabolic diseases that have reached epidemic proportions worldwide. Although their etiology is complex, both result from interplay between behaviour, environment and genetic factors. Within ambient determinants, human overall gut bacteria have been identified as a crucial mediator of obesity and its consequences. Gut microbiota plays a crucial role in gastro-intestinal mucosa permeability and regulates the fermentation and absorption of dietary polyssacharides, which may explain its importance in the regulation of fat accumulation and the resultant development of obesity-related diseases. The main objective of this review is to address the pathogenic association between gut microbiota and obesity and to explore related innovative therapeutic targets. New insights into the role of the small bowel and gut microbiota in diabetes and obesity may make possible the development of integrated strategies to prevent and treat these metabolic disorders.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12