Role of oxidative stress in the pathophysiology of arterial hypertension and heart failure

• Type: Chapter or Part of a Book
• Date: 2019

Authors

Sousa, T (Author) FMUP; Marta R Couto (Author) FMUP; Pedro Gomes (Author) FMUP

Book

Title: Oxidative Stress in Heart Diseases

Pages: 509-537

Indexing

Scopus - 8 Citations

Other information

Authenticus ID: P-00S-6HG

DOI: 10.1007/978-981-13-8273-4_23

Abstract (EN): Oxidative stress is an imbalance between endogenous prooxidant and antioxidant systems leading to excessive production of reactive oxygen species (ROS), which potentially disrupt redox signalling and/or inflict damage to macromolecules. Numerous studies over the last two decades have suggested a central role for oxidative stress in the development of several cardiovascular diseases. This chapter aims to summarize the current experimental and clinical evidence about the major oxidant and antioxidant changes occurring in hypertension and heart failure, and to provide a critical overview of the relevance of oxidative stress in the pathophysiology of these prevalent diseases. Finally, the strategies known to prevent or ameliorate oxidative damage, both in animal models and in patients, will be discussed. © Springer Nature Singapore Pte Ltd. 2019.

Language: English

Type (Professor's evaluation): Scientific