Anticoagulation after intracerebral hemorrhage in patients with atrial fibrillation: between Scylla and Charybdis

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Abrantes, CS (Author) Other; Pintalhão M (Author) FMUP; Tavares, S (Author) Other; Fonseca, L (Author) FMUP; Castro-Chaves P (Author) FMUP

Journal

Title: Neurological Sciences

Vol. 43

Pages: 2441-2448

ISSN: 1590-1874

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 1 Citation

Other information

Authenticus ID: P-00V-FE1

DOI: 10.1007/s10072-021-05602-7

Abstract (EN): Background Oral anticoagulants (OAC) are indicated in patients with atrial fibrillation (AF) and high risk of ischemic stroke. However, the introduction of anticoagulation in patients with AF and previous intracerebral hemorrhage (ICH) is controversial. We aimed to better understand the efficacy and safety of OAC in this context and to assess the factors that may influence this decision. Methods In a single-center retrospective observational study, patients with AF and ICH who survived hospitalization at a level A Stroke Unit between 2009 and 2018 were included. Patients were followed for two years after discharge. Data were collected regarding the introduction or not of OAC and the occurrence of major thrombotic/hemorrhagic events and death. Results Ninety-five patients (75.2 +/- 9.9 years) were included and 40 patients (42.1%) started OAC. Patients were more likely to initiate anticoagulation if they had: mechanical prosthetic valves, previous AF (p = 0.005) and previous OAC therapy (p < 0001); and less if they had previous hemorrhagic stroke (p < 0.005). During follow-up, 10.5% had at least one major hemorrhagic event (60% anticoagulated), 20% had at least one major thrombotic event (all non-anticoagulated) and 20% died. The only factor associated with the risk of bleeding was ICH score (OR:2.49 per 1-point increase; 95%CI:1.14-5.46). Patients who initiated anticoagulation had lower mortality than non-anticoagulated (OR:0.296; 95%CI:0.090-0-975). Previous ICH and higher CHA(2)DS(2)-VASc were associated with higher mortality. Conclusion In this retrospective series, anticoagulation reduced thrombotic events and overall mortality in patients admitted for ICH and AF, without a significant increase in bleeding risk.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8