La función diastólica se altera en pacientes con prehipertensión: datos del estudio EPIPorto

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Ladeiras-Lopes, R (Author) Other; Fontes-Carvalho R (Author) FMUP; Vilela, EM (Author) Other; Bettencourt, P (Author) Other; Leite-Moreira AF (Author) FMUP; Azevedo, A (Author) Other

Journal

Title: Revista Espanola de Cardiologia

Vol. 71

Pages: 926-934

ISSN: 0300-8932

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00Q-AQ4

DOI: 10.1016/j.recesp.2017.10.054

Abstract (EN): Introduction and objectives: Hypertension causes subclinical changes in left ventricular structure and function, namely diastolic dysfunction. Diastolic dysfunction is a predictor of heart failure, being involved in the association between hypertension and heart failure with preserved ejection fraction. We aimed to determine whether patients with prehypertension have early changes in diastolic function in a large community-based cohort of asymptomatic adults. Methods: A cross-sectional evaluation was performed of a community-based cohort consisting of 925 adults, aged 45 years or older, without known cardiovascular disease. All participants underwent detailed clinical and echocardiographic examination. The participants were categorized according to the European guidelines for the classification of office blood pressure (BP) levels as optimal, prehypertensive (normal and high-normal categories), and hypertensive. Diastolic function was evaluated by echocardiography using e' velocities and E/e' ratio. Diastolic dysfunction was defined using the 2016 ASE/EACVI Joint Recommendations and a 2017 clinically-oriented algorithm. Results: In this cohort (61.5 +/- 10.5 years; 37% men), prehypertension was present in 30.4% and hypertension in 51.0%. Using optimal BP as the reference, there was a progressive decrease of e' velocity in prehypertensive and hypertensive individuals (12.2 +/- 3.5 vs 11.3 +/- 3.1 vs 9.6 +/- 2.9 cm/s, respectively; P for trend < .001). After multivariable adjustment, both BP categories were independent predictors of a lower e' velocity (beta = -0.56, P = .035 for prehypertension and (beta = -1.08, P < .001 for hypertension). Conclusions: In this large community-based cohort, adults with prehypertension already showed impaired cardiac relaxation before the onset of hypertension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9