Prognostic Value of Osteoprotegerin in Acute Heart Failure

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Friões F (Author) FMUP; Laszczynska, O (Author) Other; Almeida, PB (Author) Other; Silva, N (Author) Other; guimaraes, jt (Author) FMUP; Omland, T (Author) Other; Azevedo A (Author) FMUP; Bettencourt P (Author) FMUP

Journal

Title: Canadian Journal of Cardiology

Vol. 31

Pages: 1266-1271

ISSN: 0828-282X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00G-MYE

DOI: 10.1016/j.cjca.2015.04.003

Abstract (EN): Background: Osteoprotegerin (OPG) is promising as a predictor of adverse prognosis in patients with acute coronary syndromes and chronic heart failure. Its prognostic value in acute heart failure (AHF) is unknown. The aim of this study was to assess the prognostic value provided by serum OPG levels at discharge after an admission for AHF. Methods: In a prospective study, we enrolled 338 patients consecutively admitted with AHF to the internal medicine department of a tertiary care university hospital in Porto, Portugal between March 2009 and December 2010. OPG was measured using a commercial enzyme-linked immunosorbent assay and was both analyzed as a continuous variable and categorized by quartiles. Patients were followed for up to 6 months after discharge to ascertain the occurrence of all-cause death or hospital readmission resulting from AHF. Results: During follow-up, 119 patients died or were readmitted for AHF. A graded increase in the risk of the combined end point was observed across quartiles of OPG. At 6 months, the cumulative risk of the end point was 25% for the first quartile and 50% for the fourth quartile. The multivariable adjusted risk of death or hospitalization for AHF increased progressively across categories of OPG up to a statistically significant 2.44-fold increase in risk in the highest category (P for linear trend = 0.002, ie, by 5% per 10 pgmL increase in OPG). Conclusions: Serum OPG was directly associated with a higher probability of death or readmission for AHF within 6 months, irrespective of other known prognostic markers. This was true both when the ejection fraction was preserved and when it was reduced.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6