The inflammatory response in the regression of lumbar disc herniation

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Cunha, C (Author) Other; Silva, AJ (Author) Other; Paulo Pereira (Author) FMUP; Rui Vaz (Author) FMUP; Goncalves, RM (Author) Other; Barbosa, MA (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: ARTHRITIS RESEARCH & THERAPY

Vol. 20

Final page: 251

ISSN: 1478-6354

Indexing

ISI Web of Knowledge - 125 Citations

Scopus - 137 Citations

Other information

Authenticus ID: P-00P-VYJ

DOI: 10.1186/s13075-018-1743-4

Abstract (EN): Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that may lead to pain. However, inflammation has also been indicated as the main factor responsible for LDH regression. This apparent controversy places inflammation as a good prognostic indicator of spontaneous regression of LDH. This review addresses the molecular and cellular mechanisms involved in LDH regression, including matrix remodeling and neovascularization, in the scope of the clinical decision on conservative versus surgical intervention. Based on the evidence, a special focus on the inflammatory response in the LDH context is given, particularly in the monocyte/macrophage role. The phenomenon of spontaneous regression of LDH, extensively reported in the literature, is therefore analyzed here under the perspective of the modulatory role of inflammation.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9