Medullary control of nociceptive transmission: Reciprocal dual communication with the spinal cord

• Type: Another Publication in an International Scientific Journal
• Date: 2006

Authors

Almeida, A (Author) Other; Leite Almeida, H (Author) Other; Isaura Tavares (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Drug Discovery Today: Disease Mechanisms

Vol. 3

Pages: 305-312

ISSN: 1740-6765

Publisher: Elsevier B.V.

Indexing

Scopus - 18 Citations

Other information

Authenticus ID: P-007-H1S

DOI: 10.1016/j.ddmec.2006.09.001

Abstract (EN): Control of pain perception, essential for organism surviving and recovery from disease, is exerted by higher brain centers integrating nociception with emotional and cognitive information and modulating the brainstem-spinal feedback loops that regulate spinal nociceptive transmission. Development of chronic pain deregulates the forebrain-brainstem-spinal pain control system, which leads to neuroplasticity and disruption of a balanced brain-spinal communication. Targets for impeding pain chronification are being developed using the manipulation of the cross talk between brain and dorsal horn, at both sites of the loop.

Language: English

Type (Professor's evaluation): Scientific