From the cytoskeleton to the nucleus: An integrated view on early spindle assembly

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Nunes, V (Author) Other; J Ferreira (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ISSN: 1084-9521

Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-A7D

DOI: 10.1016/j.semcdb.2021.03.006

Abstract (EN): Accurate chromosome segregation requires a complete restructuring of cellular organization. Microtubules remodel to assemble a mitotic spindle and the actin cytoskeleton rearranges to form a stiff actomyosin cortex. These cytoplasmic events must be spatially and temporally coordinated with mitotic chromosome condensation and nuclear envelope permeabilization, in order to ensure mitotic timing and fidelity. Here, we discuss the main cytoskeletal and nuclear events that occur during mitotic entry in proliferating animal cells, focusing on their coordinated contribution for early mitotic spindle assembly. We will also explore recent progress in understanding their regulatory biochemical and mechanical pathways. © 2021 Elsevier Ltd

Language: English

Type (Professor's evaluation): Scientific