SPINAL C-FOS EXPRESSION IS DIFFERENTIALLY INDUCED BY BRIEF OR PERSISTENT NOXIOUS-STIMULATION

• Type: Article in International Scientific Journal
• Date: 1994

Authors

Deolinda Lima (Author) FMUP; António Avelino Silva (Author) FMUP

Journal

Title: NeuroReport

Vol. 5

Pages: 1853-1856

ISSN: 0959-4965

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 32 Citations

Other information

Authenticus ID: P-001-JFP

DOI: 10.1097/00001756-199410000-00003

Abstract (EN): THE influence of stimulus duration on spinal induction of the c-fos proto-oncogene was analysed in the rat by pinching or heating the skin for periods varying from 20 s to 2 h. At stimulation periods shorter than 20 min, c-fos activation occurred in laminae I-IIi following mechanical stimulation and I-IIo following thermal stimulation. Mechanical stimulation produced delayed activation in laminae III-IV, V and VII at 30 min, 60 min and 2 h, respectively, and thermal stimulation in lamina IIi at 50 min. It is suggested that late c-fos activation signals inflammatory pain and is due to sensitization of primary afferent neurones.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4