Low Bone Volume-A Risk Factor for Coronary Calcifications in Hemodialysis Patients

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Adragao, T (Author) Other; Herberth, J (Author) Other; Monier Faugere, MC (Author) Other; Branscum, AJ (Author) Other; Ferreira, A (Author) Other; João Frazão (Author) FMUP; Curto, JD (Author) Other; Malluche, HH (Author) Other

Journal

Title: Clinical journal of the American Society of Nephrology : CJASN

Vol. 4

Pages: 450-455

ISSN: 1555-9041

Publisher: American Society of Nephrology

Indexing

ISI Web of Knowledge - 85 Citations

Scopus - 93 Citations

Other information

Authenticus ID: P-003-NC6

DOI: 10.2215/cjn.01870408

Abstract (EN): Background and objectives: There is increasing evidence that altered bone metabolism is associated with cardiovascular calcifications in patients with stage 5 chronic kidney disease on hemodialysis (HD). This study was conducted to evaluate the association between bone volume, turnover, and coronary calcifications in HD patients. Design, setting, participants, & measurements: In a cross-sectional study, bone biopsies and multislice computed tomography were performed in 38 HD patients. Bone volume/total volume, activation frequency, and bone formation rate/bone surface were determined by histomorphometry and coronary calcifications were quantified by Agatston scores. Results: Prevalence of low bone turnover was 50% and of low bone volume was 16%. Among the studied traditional cardiovascular risk factors, only age was found to be associated with coronary calcifications. Lower bone volume was a significant risk factor for coronary calcifications during early years of HD, whereas this effect was not observed in patients with dialysis duration >6 yr. Histomorphometric parameters of bone turnover were not associated with coronary calcifications. Conclusions: Low bone volume is associated with increased coronary calcifications in patients on HD.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6