The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Mesquita, I (Author) Other; Ferreira, C (Author) Other; Barbosa, AM (Author) Other; Ferreira, CM (Author) Other; Moreira, D (Author) Other; Carvalho, A (Author) Other; Cunha, C (Author) Other; Rodrigues, F (Author) Other; Ricardo Jorge Dinis Oliveira (Author) FMUP; Estaquier, J (Author) Other; Castro, AG (Author) Other; Torrado, E (Author) Other; Silvestre, R (Author) Other

Journal

Title: Cytokine

Vol. 112

Pages: 16-20

ISSN: 1043-4666

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-00P-1XH

DOI: 10.1016/j.cyto.2018.07.001

Abstract (EN): Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of L. donovani infection by analyzing the parasite burden in the spleen and liver of the infected pMT-10 and WT mice as well as the histopathological alterations upon IL-10 induction. Furthermore, the profile of cytokines expressed by T cells was assessed. Our results demonstrate that an increase in IL-10 production has an impact early but not later after infection. This specific temporal role for IL-10-mediated susceptibility to VL is of interest.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5