Gastric microbiota and carcinogenesis: the role of non-Helicobacter pylori bacteria - A systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Dias Jacome, E (Author) Other; Libanio, D (Author) FMUP; Borges Canha, M (Author) Other; Galaghar, A (Author) Other; Pedro Pimentel-Nunes (Author) FMUP

Journal

Title: Revista Espanola de Enfermedades Digestivas

Vol. 108

Pages: 530-540

ISSN: 1130-0108

Publisher: Aran Ediciones SA

Indexing

ISI Web of Knowledge - 58 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-00M-3DC

DOI: 10.17235/reed.2016.4261/2016

Abstract (EN): Background and aim: Helicobacter pylori is the strongest risk factor for gastric cancer. However, recent advances in DNA sequencing technology have revealed a complex microbial community in the stomach that could also contribute to the development of gastric cancer. The aim of this study was to present recent scientific evidence regarding the role of non-Helicobacter pylori bacteria in gastric carcinogenesis. Methods: A systematic review of original articles published in PubMed in the last ten years related to gastric microbiota and gastric cancer in humans was performed. Results: Thirteen original articles were included. The constitution of gastric microbiota appears to be significantly affected by gastric cancer and premalignant lesions. In fact, differences in gastric microbiota have been documented, depending on Helicobacter pylori status and gastric conditions, such as non-atrophic gastritis, intestinal metaplasia and cancer. Gastric carcinogenesis can be associated with an increase in many bacteria (such as Lactobacillus coleohominis, Klebsiella pneumoniae or Acinetobacter baumannii) as well as decrease in others (such as Porphyromonas spp, Neisseria spp, Prevotella pollens or Streptococcus sinensis). However, there is no conclusive data that confirms if these changes in microbiota are a cause or consequence of the process of carcinogenesis. Conclusions: Even though there is limited evidence in humans, microbiota differences between normal individuals, pre malignant lesions and gastric cancer could suggest a progressive shift in the constitution of gastric microbiota in carcinogenesis, possibly resulting from a complex cross-talk between gastric micro biota and Helicobacter pylori. However, further studies are needed to elucidate the specific role (if any) of different microorganisms.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11