Enhancement of product selectivity via enzyme immobilization in sequential degradation reactions of polymeric substrates

• Type: Article in International Scientific Journal
• Date: 1996

Authors

Varga, S (Author) Other; F. Xavier Malcata (Author) Other

Journal

Title: Bioprocess Engineering

Vol. 15

Pages: 189-194

ISSN: 0178-515X

Publisher: Springer

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-001-DQD

DOI: 10.1007/s004490050254

Abstract (EN): The balance equations pertaining to the modelling of a slap-shaped bead containing immobilized enzyme uniformly distributed which catalyzes the sequential reactions of degradation of a polymeric substrate were written and analytically solved in dimensionless form. The effect of the Thiele modulus on the selectivity of consumption of each multimeric product was studied for a simple case. Whereas plain diffusional regime leads to lower selectivities than plain kinetic regime, improvements in selectivity of species A(i) relative to species A(i+1) may be obtained at the expense of higher Thiele moduli within a limited range when the diffusivity of A(i) is larger than that of A(i+1), or when the pseudo first order kinetic constant describing the rate of consumption of A(i) is lower than that of A(i+1).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6