On the optimum distribution of enzyme feed in a cascade of CSTR's performing an enzyme-catalyzed reaction with deactivation

• Type: Article in International Scientific Journal
• Date: 1996

Authors

Moreira, NE (Author) Other; F. Xavier Malcata (Author) Other

Journal

Title: Bioprocess Engineering

Vol. 15

Pages: 301-306

ISSN: 0178-515X

Publisher: Springer

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-001-DDM

DOI: 10.1007/s004490050271

Abstract (EN): A search for the optimum fractional distribution of an enzyme-rich stream to the various reactors of a cascade of CSTR's was implemented. A theoretical analysis, laid out in dimensionless form and based on the assumptions that the system is operated under steady state conditions, the enzyme undergoes first order deactivation, and the reaction catalyzed by the enzyme follows Michaelis-Menten kinetics, is reported. The objective function utilised is the minimisation of the overall volume of the cascade, and analytical expressions are obtained for the concentration of active enzyme and substrate in the outlet stream from each reactor. It is found that the best option is to add the whole enzyme-rich stream to the first reactor in the cascade irrespective of the operating and kinetic parameters of the system.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6