Determination of the optimum operating time for batch isothermal performance of enzyme-catalyzed multisubstrate reactions

• Type: Article in International Scientific Journal
• Date: 1994

Authors

F. Xavier Malcata (Author) Other

Journal

Title: Bioprocess Engineering

Vol. 10

Pages: 173-178

ISSN: 0178-515X

Publisher: Springer

Indexing

Scopus - 2 Citations

Other information

Authenticus ID: P-00F-GP8

DOI: 10.1007/s004490050041

Abstract (EN): This communication consists of a mathematical analysis encompassing the maximization of the average rate of monomer production in a batch reactor performing an enzymatic reaction in a system consisting of a multiplicity of polymeric substrates which compete with one another for the active site of a soluble enzyme, under the assumption that the form of the rate expression is consistent with the Michaelis-Menten mechanism. The general form for the functional dependence of the various substrate concentrations on time is obtained in dimensionless form using matrix terminology; the optimum batch time is found for a simpler situation and the effect of various process and system variables thereon is discussed. The reasoning developed here emphasizes, in a quantitative fashion, the fact that the commonly used lumped substrate approaches lead to nonconservative decisions in industrial practice, and hence should be avoided when searching for trustworthy estimates of optimum operation.

Language: English

Type (Professor's evaluation): Scientific