How performance of a recycle plug flow reactor is optimized for protease-driven autocatalytic reactions

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Allegro, CS (Author) Other; F. Xavier Malcata (Author) Other

Journal

Title: Bioprocess Engineering

Vol. 19 No. 6

Pages: 331-335

ISSN: 0178-515X

Publisher: Springer

Indexing

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Other information

Authenticus ID: P-001-6SR

DOI: 10.1007/s004490050528

Abstract (EN): The balance equations to a continuous plug flow recycle reactor performing a protease-mediated autocatalytic reaction were analytically developed under the assumption of a Michaelis-Menten type of mechanism. The necessary condition for the recycle ratio that leads to the minimum reactor volume was set up and the resulting expression was numerically solved for the optimum ratio of recycle, R-opt, as a function of the desired conversion of reactant (or pro-enzyme) into product (or enzyme), XP-E, for selected values of the relevant dimensionless parameters, i.e. the ratio of total concentrations of enzyme and product moieties, gamma, and the ratio of the Michaelis-Menten parameter to the total concentration of product moisty, K-m*. It was numerically proven that variation of K-m* by five orders of magnitude centered around unity did not affect R-opt to a significant extent, whereas an empirical expression for R-opt versus gamma and XP-E could be found and successfully fitted to the results of several numerical runs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5