AN OPEN STUDY OF SELF-ADMINISTRATION OF SUBCUTANEOUS SUMATRIPTAN TO TREAT SUCCESSIVE ATTACKS OF ACUTE MIGRAINE

• Type: Article in International Scientific Journal
• Date: 1994

Authors

MONTEIRO, P (Author) Other; SEABRA, E (Author) Other; PALMEIRO, J (Author) Other; PAIVA, T (Author) Other; PONTES, C (Author) Other; SANTOS, G (Author) Other; ALENTISCA, F (Author) Other; ARAUJO, C (Author) Other; ESPERANCA, M (Author) Other; FONTES, J (Author) Other; HENRIQUES, P (Author) Other; JORGE, A (Author) Other; LEITAO, A (Author) Other; Lopes, C (Author) FMUP; MACHADO, J (Author) Other; MORAIS, C (Author) Other; NEVES, G (Author) Other; PEREIRA, M (Author) Other; SA, M (Author) Other; SANTOS, J (Author) Other; AFONSO, A (Author) Other; COELHO, I (Author) Other; COUCELO, J (Author) Other; LEITAO, O (Author) Other; MARINHO, M (Author) Other; MORGADO, R (Author) Other; RIBEIRO, N (Author) Other; SANGUESSUGA, H (Author) Other; VASCONCELOS, J (Author) Other; Jose Barros (Author) Other; CORREIA, C (Author) Other; RIBEIRO, F (Author) Other; SOUSA, L (Author) Other; RAMOS, I (Author) Other; MESTRE, A (Author) Other; CASIMIRO, M (Author) Other; SA, JPAE (Author) Other; LUZEIRO, I (Author) Other; RAMOS, H (Author) Other; PAVAO, I (Author) Other; ESPERANCA, P (Author) Other; PALMEIRA, M (Author) Other; VIEIRA, S (Author) Other; ALMEIDA, M (Author) Other; MARQUES, P (Author) Other; RENTE, J (Author) Other; FRESCO, H (Author) Other; AMARO, A (Author) Other; MOTA, R (Author) Other; BIGOTTE, M (Author) Other; PORTELINHA, D (Author) Other; GUERRA, L (Author) Other; LOPES, D (Author) Other; CARNEIRO, L (Author) Other; CARQUEJA, T (Author) Other; TEIXEIRA, C (Author) Other

Journal

Title: Journal of International Medical Research

Vol. 22

Pages: 225-235

ISSN: 0300-0605

Publisher: SAGE

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Other information

Authenticus ID: P-001-JX5

Abstract (EN): The efficacy and safety of single doses of 6 mg sumatriptan, self-administered subcutaneously by patients using an auto-injector, for the acute treatment of up to three successive attacks of migraine was investigated in a multicentre, open, uncontrolled study in which 178 patients were enrolled. At attack 1, there was an improvement in headache (from severe or moderate to mild or no headache) in 74% of patients at 1 h, and in 82% at 2 h. The incidence of symptoms associated with migraine was decreased after sumatriptan injection. Nausea, vomiting and photo/phonophobia were reported by 72, 54, and 85% of patients, respectively, before the injection to treat attack 1, but by only 22, 12 and 27%, respectively, 2 h after the injection. Migraine recurred within 24 h in 27% of patients, but in 89% of patients was effectively treated with a further dose of 6 mg sumatriptan. Results for attacks 2 and 3 were similar. About 40% of patients experienced at least one adverse event; most of these were mild or moderate in intensity and were transient. It is concluded that 6 mg sumatriptan, self-administered using an auto-injector, is an effective and well tolerated treatment for migraine. Sumatriptan was as effective at attack 3 as at attack 1, and there was no evidence of a change in the incidence or the nature of adverse events with successive uses of the drug.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11