Vitamin D and Postoperative Hypoparathyroidism: Random Relationship?

• Type: Article in National Scientific Journal
• Date: 2020

Authors

Devezas, V (Author) Other; Sa Vinhas, L (Author) Other; Santos Sousa, H (Author) FMUP; Matos Lima, L (Author) Other; Barbosa, LE (Author) Other

Journal

Title: Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo

Vol. 15 No. 1-2

Pages: 51-54

ISSN: 1646-3439

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00T-G1A

DOI: 10.26497/ao190040

Abstract (EN): Introduction: Hypoparathyroidism after total thyroidectomy may be transient or permanent, according to its duration. In high volume centers, the rate of hypoparathyroidism is expected to be up to 2%, and may reach to 15% if associated with central compartment lymphadenectomy. Since vitamin D levels influence intestinal absorption of calcium and parathyroid hormone release, it is hypothesized that hypovitaminosis D may influence postoperative hypocalcemia. Methods: We carry out a prospective, non-randomized, study in a tertiary hospital, with an intentional non-probabilistic sample (consecutive), from 1-1-2018 to 15-9-2018 with 186 patients undergoing total thyroidectomy. Results: The median vitamin D levels were 17 ng/mL. We diagnosed 32 cases (17.2%) of hypoparathyroidism, being definitive in only 1 case (0.54%). Hypocalcemia with parathyroid hormone within reference values ("inappropriately" normal parathyroid hormone hypoparathyroidism), was diagnosed in 82 cases (44.1%). No statistically significant association was found between vitamin D levels and hypoparathyroidism (p = 0.360) nor hypocalcemia (p = 0.247). Moreover, no significant association was found between hypoparathyroidism nor hypocalcemia, and the following variables: gender, malignancy, ASA classification, surgeon experience or type of vascular ligation. Conclusion: This study concludes that preoperative vitamin D levels do not appear to influence the prevalence or severity of postoperative hypoparathyroidism or hypocalcemia, after total thyroidectomy. The proportion of definitive hypoparathyroidism was 0.54%, similar to the one described for European tertiary centers.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 4