Quality of Life in Children Diagnosed With Non- classic Congenital Adrenal Hyperplasia

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Ferreira, MJ (Author) Other; Moita, R (Author) Other; Canha, M (Author) Other; Ferreira, S (Author) Other; Costa, C (Author) FMUP; Almeida, P (Author) Other; Castedo, JL (Author) Other; Carvalho, Davide (Author) FMUP; C Correia (Author) FMUP

Journal

Title: CUREUS

Vol. 13

ISSN: 2168-8184

Indexing

ISI Web of Knowledge - 1 Citation

Other information

Authenticus ID: P-00V-N02

DOI: 10.7759/cureus.18937

Abstract (EN): Background Non-classical congenital adrenal hyperplasia (NC-CAH) is a chronic disease characterised by excessive androgen production that may negatively affect the quality of life (QoL) of affected patients. Pediatric Quality of Life Inventory 4.0 (PedsQLTM) is a validated tool to assess health-related QoL (HRQoL). Methods A cross-sectional study including 19 patients with NC-CAH was carried out in the pediatric endocrinology department. NC-CAH patients who agreed to participate were included. Anthropometric data was collected. PedsQLTM was applied to the patients and their parents. Patients were divided into four groups according to age: 2-4, 5-7, 8-12, and 13-18 years old. The control group consisted of healthy individuals from the instrument's validation studies for the Portuguese population and the standard control population used in the PedsQLTM validation study. Results The only difference found concerns the parents' score results for children aged 8-12, which showed physical health and emotional dimension scores significantly higher (86.16 +/- 9.86 vs. 68.90 +/- 23.02 p=0.004, 69.17 +/- 14.14 vs. 65.82 +/- 19.24 p=0.004), while psychosocial health's score and total scale score were significantly lower than the control group (59.99 +/- 9.90 vs. 69.34 +/- 14.07 p=0.047, 73.11 +/- 4.65 vs. 78.86 +/- 16.61 p=0.017). Conclusion HRQoL scores are not negatively affected by NC-CAH in most group ages, with the exception of the parents' reports on HRQoL for children aged 8-12. Further studies with a greater number of patients are needed to determine the impact of this chronic disease on the HRQoL of children.

Language: English

Type (Professor's evaluation): Dissemination

No. of pages: 10