Suppression of tumorigenicity 2 after exercise: a systematic review

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Costa, AM (Author) Other; Teixeira, R (Author) Other; Vilela, EM (Author) Other; Tavares, A (Author) Other; Torres, S (Author) Other; Sampaio, F (Author) Other; Teixeira, M (Author) Other; Fontes-Carvalho R (Author) FMUP; José Pedro Nunes (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: Monaldi Archives for Chest Disease

Vol. 92

ISSN: 1122-0643

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-XA6

DOI: 10.4081/monaldi.2021.1839

Abstract (EN): Exercise is a pivotal physiological activity, associated with benefits. Whilst the importance of physical activity is consensual along different steps of the cardiovascular (CV) continuum, there has been interest in assessing the CV adaptations to vigorous exercise. Indeed, exercise can be associated with increases in cardiac biomarkers, though the scope of this observation remains elusive. Interleukin I receptor related protein, Suppression of tumorigenicity 2 (ST2) is a biomarker related to the pathophysiology of fibrosis, having shown promise in the study of heart failure. Knowledge of ST2 kinetics could improve understanding of the mechanistic pathways related to CV adaptations to exercise. To assess the current state-of-the-art concerning ST2 levels after exercise in healthy individuals. A systematic review was carried out on three databases (Pubmed, ISI Web of Science and Scopus), up to October 2020, using the queries ST2 or ST-2 exercise or running. A total of six studies were included in the review, encompassing 349 subjects (73% male gender) in which ST2 was assessed. Most studies reported increases in ST2 levels after exercise. Three studies, encompassing a total of 219 individuals, described a cut-off level of 35 ng/dL for ST2. In these, 92.7% of subjects had ST2 levels above this cut-off after exercise (running in all studies). Most studies report increased levels of ST2 after exercise, with an important number of individuals exceeding the 35 ng/dL threshold. Given the small number of individuals represented and the lack of imaging data and long-term follow-up, further prospective larger studies should target this.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7