Evaluation of nickel toxicity on liver, spleen, and kidney of mice after administration of high-dose metal ion

• Type: Article in International Scientific Journal
• Date: 1998

Authors

Pereira, MC (Author) Other; Pereira, ML (Author) Other; Sousa, JP (Author) Other

Journal

Title: Journal of Biomedical Materials Research

Vol. 40

Pages: 40-47

ISSN: 0021-9304

Publisher: Heterocorporation

Indexing

ISI Web of Knowledge - 39 Citations

Scopus - 40 Citations

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Other information

Authenticus ID: P-001-86P

DOI: 10.1002/(sici)1097-4636(199804)40:1<40::aid-jbm5>3.0.co;2-r

Abstract (EN): The toxic effects caused by nickel (Ni) per si were explored by performing in vivo studies on mice following subcutaneous administration of a metallic solution of nickel at 1, 2, 3, and 4 weeks to evaluate the side effects of this metal ion when released from stainless steel implants. Other groups were similarly injected with HBSS and used as controls. Accumulation of Ni ions on liver, spleen, and kidney was assessed by an electrochemical method, adsorptive stripping voltammetry (AdSV) using microelectrodes, and atomic absorption spectrometry (AAS). Alterations of those organs induced by Ni ions were studied, showing that several histological changes had been induced. Chemical analysis and histological features indicate that Ni is partially accumulated in the study organs. (C) 1998 John Wiley & Sons, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8