Supramolecular Atropine Potentiometric Sensor

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Ferreira, C (Author) Other; Palmeira, A (Author) FFUP; Emilia Sousa (Author) FFUP; Amorim, CG (Author) FFUP; Araujo, AN (Author) FFUP; Montenegro, MCBSM (Author) FFUP

Journal

Title: Sensors

Vol. 21 No. 2

Final page: 5879

ISSN: 1424-3210

Publisher: MDPI

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00V-BG9

DOI: 10.3390/s21175879

Abstract (EN): A supramolecular atropine sensor was developed, using cucurbit[6]uril as the recognition element. The solid-contact electrode is based on a polymeric membrane incorporating cucurbit[6]uril (CB[6]) as an ionophore, 2-nitrophenyl octyl ether as a solvent mediator, and potassium tetrakis (4-chlorophenyl) borate as an additive. In a MES-NaOH buffer at pH 6, the performance of the atropine sensor is characterized by a slope of (58.7 +/- 0.6) mV/dec with a practical detection limit of (6.30 +/- 1.62) x 10(-7) mol/L and a lower limit of the linear range of (1.52 +/- 0.64) x 10(-6) mol/L. Selectivity coefficients were determined for different ions and excipients. The obtained results were bolstered by the docking and spectroscopic studies which demonstrated the interaction between atropine and CB[6]. The accuracy of the potentiometric analysis of atropine content in certified reference material was evaluated by the t-Student test. The herein proposed sensor answers the need for reliable methods providing better management of this hospital drug shelf-life while reducing its flush and remediation costs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12