Challenges in Cytology Specimens With Hurthle Cells

• Type: Article in International Scientific Journal
• Date: 2021

Authors

Thodou, E (Author) Other; Canberk, S (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Frontiers In Endocrinology

Vol. 12

ISSN: 1664-2392

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 8 Citations

Other information

Authenticus ID: P-00V-6AB

DOI: 10.3389/fendo.2021.701877

Abstract (EN): In fine-needle aspirations (FNA) of thyroid, Hurthle cells can be found in a broad spectrum of lesions, ranging from non-neoplastic conditions to aggressive malignant tumors. Recognize them morphologically, frequently represents a challenging for an adequately diagnosis and are associated with a significant interobserver variability. Although the limitations of the morphologic diagnosis still exist, the interpretation of the context where the cells appear and the recent advances in the molecular knowledge of Hurthle cells tumors are contributing for a more precise diagnosis. This review aims to describe the cytology aspects of all Hurthle cells neoplastic and non-neoplastic thyroid lesions, focusing on the differential diagnosis and reporting according to The Bethesda System for Reporting Thyroid Cytology (TBSRTC). New entities according to the latest World Health Organization (WHO) classification are included, as well as an update of the current molecular data.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11