Expression of p53, Ki-67 and c-erb B2 in growth hormone- and/or prolactin-secreting pituitary adenomas

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Botelho, CHA (Author) Other; de Magalhaes, AVD (Author) Other; de Mello, PA (Author) Other; Fernando Schmitt (Author) FMUP; Casulari, LA (Author) Other

Journal

Title: Arquivos de Neuro-Psiquiatria

Vol. 64

Pages: 60-66

ISSN: 0004-282X

Publisher: Associacao Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 31 Citations

Other information

Authenticus ID: P-004-MVC

DOI: 10.1590/s0004-282x2006000100013

Abstract (EN): The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). The analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb B2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for Ki-67. Our results demonstrated a high percentage of GH/prolactin-, prolactin- and GH-secreting tumors with immunohistochemical positivity for c-erb B2. Once this membrane receptor is related to growth factors EGF and TGF alpha and both have a definite effect on tumor growth, our data suggest a possible role for c-erb B2 on the evolution of these tumors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7