Apocrine carcinoma of the breast: A comprehensive review

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Vranic, S (Author) Other; Fernando Schmitt (Author) FMUP; Sapino, A (Author) Other; Costa, JL (Author) Other; Reddy, S (Author) Other; Castro, M (Author) Other; Gatalica, Z (Author) Other

Journal

Title: Histology and Histopathology

Vol. 28

Pages: 1393-1409

ISSN: 0213-3911

Publisher: Plaza Fuensanta

Indexing

ISI Web of Knowledge - 68 Citations

Scopus - 72 Citations

Other information

Authenticus ID: P-006-69V

Abstract (EN): Apocrine carcinoma of the breast is a rare, special type of breast carcinoma showing distinct morphologic, immunohistochemical and molecular genetic features. Apocrine epithelium has a characteristic steroid receptor profile that is estrogen receptor and progesterone receptor negative and androgen receptor positive. This combination of morphologic and immunohistochemical characteristics is essential for the proper recognition of the apocrine carcinomas. Strictly defined, apocrine carcinomas express either Her-2/neu or EGFR, which along with androgen receptor positivity make patients with the apocrine carcinoma eligible for targeted therapies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17