The new guidelines of Papanicolaou Society of Cytopathology for respiratory specimens: Assessment of risk of malignancy and diagnostic yield in different cytological modalities

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Canberk, S (Author) Other; Montezuma, D (Author) Other; Aydin, O (Author) Other; Demirhas, MP (Author) Other; Denizci, B (Author) Other; Akbas, M (Author) Other; Caliskan, C (Author) Other; Tokat, F (Author) Other; Ince, U (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Diagnostic Cytopathology

Vol. 46

Pages: 725-729

ISSN: 8755-1039

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 23 Citations

Other information

Authenticus ID: P-00P-S7K

DOI: 10.1002/dc.24036

Abstract (EN): BackgroundMethodsIn 2016, the Papanicolaou Society of Cytopathology (PSC) issued a new classification scheme for respiratory cytology. We aim to evaluate our samples according to this classification and to assess risk of malignancy and diagnostic yield of different cytological modalities. Respiratory specimens (sputum, bronchial wash/brush, BAL and FNA) obtained between 2007 and 2016 were reclassified according to PSC guidelines. Risk of malignancy for each diagnostic category was determined. Diagnostic yield was evaluated based on three-categorical approach. ResultsConclusionOne thousand, two hundred and ninety respiratory specimens were retrieved, of which 280 had histologic follow-up. Samples were reclassified as nondiagnostic 16%, negative for malignancy 53%, atypical 5.4%, neoplastic (benign neoplasm/low-grade carcinoma) 0.4%, suspicious for malignancy 2.1% and malignant 23.1%. Risk of malignancy for each category was 64.01% for ND, 48.27% for NM, 59.09% for A, 100% for N-B-LG; 90% for SM and 89.74% for M. When only malignant cases were considered positive tests, cytology sensitivity was 55% and specificity 88%. Our results were in line with PSC guidelines, but the use of multiple cytological techniques may cause some discrepancies in overall diagnostic yield and in estimated risks of malignancy, which is important due to the widespread utilization of different cytological procedures.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5