Cognitive dysfunction in Multiple Sclerosis

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Joana Guimaraes (Author) FMUP; Sa, MJ (Author) Other

Journal

Title: Frontiers in Neurology

Vol. MAY

ISSN: 1664-2295

Publisher: Frontiers Media

Indexing

Scopus - 80 Citations

Other information

Authenticus ID: P-008-604

DOI: 10.3389/fneur.2012.00074

Abstract (EN): In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45-60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing, and visual-spatial abilities); the pathophysiological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities. © 2012 Guimarães and Sá.

Language: English

Type (Professor's evaluation): Scientific