3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Viña, D (Author) Other; Matos, MJ (Author) Other; Yáñez, M (Author) Other; Santana, L (Author) Other; Uriarte, E (Author) Other

Journal

Title: MedChemComm

Vol. 3

Pages: 213-218

ISSN: 2040-2503

Publisher: Royal Society of Chemistry

Indexing

Scopus - 75 Citations

Other information

Authenticus ID: P-00R-0MP

DOI: 10.1039/c1md00221j

Abstract (EN): The complex etiology of Alzheimer's disease (AD) has encouraged active research in the development of multi-target drugs with two or more complementary biological activities, since they may represent an important advance in the treatment of this disease. A series of 3-substituted coumarins were synthesized and evaluated as monoamino oxidases (MAO) and acetylcholinesterase (AChE) inhibitors. Most of the 3-benzamide coumarin derivatives inhibited both MAO-B and AChE with values in the micromolar range. It might be a promising direction for developing novel drugs as potential agents for the treatment of AD patients. © 2012 The Royal Society of Chemistry.

Language: English

Type (Professor's evaluation): Scientific