H-1 NMR Based Metabonomics of Human Amniotic Fluid for the Metabolic Characterization of Fetus Malformations

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Graca, G (Author) Other; Duarte, IF (Author) Other; Barros, AS (Author) Other; Goodfellow, BJ (Author) Other; Diaz, S (Author) Other; Carreira, IM (Author) Other; Couceiro, AB (Author) Other; Galhano, E (Author) Other; Gil, AM (Author) Other

Journal

Title: Journal of Proteome Research

Vol. 8

Pages: 4144-4150

ISSN: 1535-3893

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 60 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-003-H5E

DOI: 10.1021/pr900386f

Abstract (EN): An NMR-metabonomic study of malformed fetuses was carried out through human amniotic fluid (HAF) analysis. Over 70 compounds were detected in control HAF by NMR. Possible confounding variables (fetus gender and gestational and maternal ages) were shown not to induce detectable compositional trends in the control group considered, Malformed fetuses showed variations in glucose, some amino acids and organic acids and proteins. In tandem with enzymatic assays, these NMR results suggest that changes in gycolysis and gluconeogenesis as well as kidney underdevelopment occur in the malformed fetuses studied here.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7