Lesion of the caudal ventrolateral medulla prevents the induction of hypertension by adenosine receptor blockade in rats

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Pinho, D (Author) Other; Sousa, T (Author) FFUP; Morato, M (Author) FFUP; Tavares, I (Author) FMUP; Albino Teixeira, A (Author) FMUP

Journal

Title: Brain Research

Vol. 1073

Pages: 374-382

ISSN: 0006-8993

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

ISI Web of Science

Scopus - 7 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Neuroscience > Neurobiology

Other information

Authenticus ID: P-004-N8B

DOI: 10.1016/j.brainres.2005.12.098

Abstract (EN): The continuous infusion for 7 days of the adenosine receptor antagonist 1,3-dipropyl-8sulfophenylxanthine (DPSPX) causes a sustained hypertension in rats, with an enhancement of sympathetic neurotrans mission and activation of the renin-angiotensin system. We studied the involvement of the caudal ventrolateral medulla in the establishment of this hypertensive model by evaluating the effect of local lesioning in blood pressure (BP). Male adult Wistar rats received stereotaxic injections of 0.3 mu l of saline or quinolinic acid (QA; 180 mM) in the caudal ventrolateral medulla followed by abdominal implant of minipump for infusion of saline or DPSPX (90 mu g(-1) kg(-1) h(-1)). BP was measured in conscious animals every 2 days for 12 days. The sustained increase of BP (22.1 mm Hg; P < 0.001) detected in rats infused with DPSPX was reverted (6.7 mm Hg; P > 0.05) from day six onwards in animals with lesion of the lateralmost part of caudal ventrolateral medulla (VLMIat). The present results suggest that the development of hypertension induced by adenosine receptor antagonist involves the participation of the VLMlat. They further add new data as to the functional complexity of this medullary area involved in a variety of functions such as cardiovascular, respiratory, motor and pain control.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9