The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Dinis P. (Author) Other; Charrua A. (Author) FCNAUP; Avelino A. (Author) FCNAUP; Nagy I. (Author) Other; Quintas J. (Author) Other; Cruz F. (Author) Other

Journal

Title: European Urology

Vol. 48

Pages: 162-167

ISSN: 0302-2838

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 43 Citations

Scopus - 55 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-000-2H7

DOI: 10.1016/j.eururo.2005.01.009

Abstract (EN): Objectives: To determine the distribution of sensory fibers immunoreactive to the pain receptor TRPV1 in the human prostate. Methods: Eight prostates were harvested from cadaver transplant donors and immediately immersion fixed. Longitudinal and transverse 20 mu m sections were cut on a cryostat and inummoreacted with two anti-human TPRV1 antibodies. Results: TRPV1-immunoreactive nerve fibers were distributed throughout the prostatic urethral mucosa, verumontanum, ejaculatory ducts and periurethral prostatic acini. In the urethral mucosa, TRPV1-immunoreactive fibers penetrated the epithelial layer up to its surface. In the transitional and peripheral zones of the gland no TRPV1-immunoreactive nerve fibers were detected. Conclusions: The existence of a rich TRPV1 sensory innervation in the human prostate may open new therapeutic perspectives for the treatment of pain in patients with chronic prostatitis (Chronic Pelvic Pain Syndrome).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6