Adipocyte size and liability to cell death

• Type: Article in International Scientific Journal
• Date: 2006

Authors

monteiro, r (Author) FCNAUP; de castro, pmst (Author) FEUP; calhau, c (Author) FMUP; azevedo, i (Author) Other

Journal

Title: Obesity Surgery

Vol. 16 No. 6

Pages: 804-806

ISSN: 0960-8923

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 55 Citations

Scopus - 64 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-KK3

DOI: 10.1381/096089206777346600

Abstract (EN): Obesity constitutes a serious health problem. Inflammation, which has recently been shown to follow adipocyte death, is at the basis of a series of pathogenic complications of obesity. Here we demonstrate, through modelling using the finite element method, that the bigger the adipocyte, the more fragile it becomes to rupture when submitted to common physical forces. This indicates that adipocyte size is an important determinant of cell death. Interventions to prevent adipocyte hypertrophy may, therefore, help to reduce the risk associated with obesity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3