Pilot study of the effects of n-3 polyunsaturated fatty acids on exhaled nitric oxide in patients with stable asthma

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Moreira, A (Author) FMUP; Moreira, P (Author) FCNAUP; Delgado, L (Author) FMUP; Fonseca, J (Author) FMUP; Teixeira, V (Author) FCNAUP; Padrao, P (Author) Other; Castel Branco, G (Author) Other

Journal

Title: Journal of Investigational Allergology and Clinical Immunology

Vol. 17 No. 5

Pages: 309-313

ISSN: 1018-9068

Publisher: Esmon Publicidad S.A.

Indexing

ISI Web of Knowledge - 30 Citations

ISI Web of Science

Scopus - 33 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-004-DPS

Abstract (EN): Background: The anti-inflammatory effects of n-3 polyunsaturated fatty acids (n-3 PUFA) have been demonstrated both in vitro and in vivo. The results of epidemiological studies suggest that fish consumption has a beneficia I effect on I ungfunction and prevalence of asthma. However, data from intervention trials have not revealed a beneficial effect of n-3 PUFA supplementation in patients with established disease. Objective: To study the effects of short-term n-3 PUFA supplementation in addition to maintenance therapy on exhaled nitric oxide in asthmatic patients. Methods: A double-blind, placebo-controlled trial was undertaken in 20 women with asthma. Patients received either a combination of eicosapentaenoic acid and docosahexaenoic acid plus 10 mg vitamin E or placebo twice daily for 2 weeks. The primary outcome measure was the fraction of exhaled nitric oxide (FeNO) and the secondary outcomes were asthma control (score on the Asthma Control Questionnaire [ACQ]) and lung function (forced expiratory volume in 1 second [FEV1]). Results: No significant differences were observed in FeNO, ACQ score, or FEV1 between patients receiving n-3 PUFA supplementation and those receiving placebo. Conclusions: Short-term dietary supplementation with n-3 PUFA in women with stable asthma was not associated with statistically significant changes in FeNO, asthma control, or lung function

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5